OKT3 Monoclonal Antibody in Cardiac Transplantation
نویسندگان
چکیده
منابع مشابه
The carbohydrate structures of a mouse monoclonal IgG antibody OKT3.
A mouse monoclonal antibody OKT3, of IgG2a isotype, was isolated from hybridoma culture fluid. Sugar analysis showed the presence of sialic acid, galactose, mannose, fucose, and N-acetylglucosamine, i.e. sugars typical for N-glycosidically linked carbohydrate chains. The absence of N-acetylgalactosamine revealed that O-glycosidically linked carbohydrates were not present. The purified antibody ...
متن کاملTreatment of acute renal allograft rejection with OKT3 monoclonal antibody.
Eight cadaver donor renal allograft recipients, who had received azathioprine and prednisone from the day of transplantation, were treated with OKT3 monoclonal antibody (reactive with all mature peripheral blood T cells) at the time of diagnosis of acute rejection. In all cases, loss of essentially all detectable peripheral blood OKT3-reactive cells was noted within minutes after the initial 1-...
متن کاملMonocyte procoagulant activity induced by in vivo administration of the OKT3 monoclonal antibody.
The first injection of OKT3 in kidney transplant recipients activates the common pathway of coagulation. This may result in early thrombosis of graft vessels. To this day, the cells involved in this phenomenon have not been identified. The aim of this study was to investigate whether circulating monocytes participated in this OKT3-induced coagulopathy. The procoagulant activity (PCA) of circula...
متن کاملOKT3 monoclonal antibody reversal of acute renal allograft rejection unresponsive to conventional immunosuppressive treatments.
Immunobiology Division, Ortho Pharmaceutical Corporation, Raritan, NJ; Oregon Health Sciences University, Division of Nephrology, Portland, OR; St. Francis Regional Medical Center, Departli1ent of Surgery, Wichita, KS; Hopital Necker, Departement de Nephrologie, Paris, France; Johns Hopkins Hospital, Di vi si on of Transpl antation/Vascul ar Surgery, Baltimore, MD; Yale University School of Med...
متن کاملCerebral complications of murine monoclonal CD3 antibody (OKT3): CT and MR findings.
Treatment of acute renal allograft rejection with mouse monoclonal antibody (OKT3) is associated with systemic and neurologic side effects. We describe cerebral abnormalities in a 13-year-old boy with steroid-resistant renal allograft rejection. After treatment with OKT3, an acute neurologic syndrome developed, including seizures, lethargy, and decreased mental function. CT and MR imaging revea...
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ژورنال
عنوان ژورنال: Annals of Surgery
سال: 1988
ISSN: 0003-4932
DOI: 10.1097/00000658-198809000-00005